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BRD 0476
CAS No. 1314958-91-2
BRD 0476 ( ML187 )
产品货号. M11273 CAS No. 1314958-91-2
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BRD 0476
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
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产品描述BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.
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同义词ML187
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通路Proteasome/Ubiquitin
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靶点DUB
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受体DUB
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研究领域——
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适应症——
化学信息
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CAS Number1314958-91-2
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分子量674.77
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分子式C35H38N4O8S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC1=C2C=CC=CC2=CC=C1)NC3=C(O[C@@H](CN(S(=O)(C4=CC=C(OCCO5)C5=C4)=O)C)[C@H](C)CN([C@@H](C)CO)C6=O)C6=CC=C3
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化学全称N-(((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-10-(3-(naphthalen-1-yl)ureido)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34.
2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.
2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.
